Home Anatomy & Physiology Extracellular Fluid


Gardnerella vaginalis

Gardnerella Vaginalis

Definition Gardnerella vaginalis is the name of a micro-aerophilic coccobacillus found in the vaginal flora. Gardnerella vaginalis does not cause bacterial vaginosis (vaginal infection) unless...
Acetic Acid

Acetic Acid

Definition Acetic acid is a mildly corrosive monocarboxylic acid. Otherwise known as ethanoic acid, methanecarboxylic acid, hydrogen acetate or ethylic acid, this organic compound is...
Amino Acids

Amino Acids

Definition Amino acids are the building blocks of polypeptides and proteins and play important roles in metabolic pathway, gene expression, and cell signal transduction regulation....
BCAA supplements: a muscle myth?

Branched Chain Amino Acids

Definition The branched-chain amino acids or BCAAs, leucine, isoleucine, and valine are three of the nine nutritionally essential amino acids. These three ingredients form a...
Sulfuric acid

Sulfuric Acid

Definition Sulfuric acid (sulphuric acid) is a corrosive mineral acid with an oily, glassy appearance that gave it its earlier name of oil of vitriol....
Bile salt action in the gut

Bile Salts

Definition Bile salts are found in bile, a secretion produced by liver cells to aid digestion. Although bile is 95% water, bile salts are its...
The salivary glands

Submandibular Gland

Definition Submandibular glands are the second-largest salivary gland type, producing around 65% of our saliva when unstimulated (at rest). Located under the jaw, the exocrine...
Metaphase I

Metaphase I

Definition The first metaphase of meisosis I encompasses the alignment of paired chromosomes along the center (metaphase plate) of a cell, ensuring that two complete...
Prophase II

Prophase II

Definition During prophase II of meiosis II, four important steps occur. These are the condensing of chromatin into chromosomes, disintegration of the nuclear envelope, migration...


Definition Aldosterone (C21H28O5) is a mineralocorticoid hormone compound secreted by the adrenal gland cortex. It is part of the renin angiotensin aldosterone system or RAAS...

Extracellular Fluid

Extracellular Fluid Definition

Extracellular fluid is the term for the many fluids that exist in an organism outside of cells of the organism, but sealed within the body cavities and vessels. Extracellular fluid that travels in the circulatory system is blood plasma, the liquid component of blood. As the oxygen and nutrients from blood are transferred out of the blood in the capillaries, these molecules make their way to another extracellular fluid that surrounds individual cells within the body. This is known as interstitial fluid, and surrounds most of the cells in the body. This extracellular fluid allows cells to carry out processes using the nutrients and oxygen provided, and to carry wastes back to the blood. The final extracellular fluid is transcellular fluid, which exists in many of the spaces in which the fluid is meant as structural support, not for the exchange of molecules. These extracellular fluids can be found in the eye, joints, and cerebrospinal fluid.

Cellular Fluid Content

In term of total volume, extracellular fluid actually constitutes a much smaller portion of the total body water than intracellular fluid, which exists within each cell of a body. This can be seen in the graph above. In all, extracellular fluid accounts for only about a third of the body’s total fluids. This is typical in humans, but the ratio may change in other organisms which have different modes of circulation.

  • Intracellular Fluid – The fluid within the cells, also called cytosol.
  • Transcellular Fluid – Fluid that exists in spaces used that do not receive circulation, and offer support or protection.
  • Interstitial Fluid – The fluid that bathes cells in the tissues of organisms.
  • Intravascular Fluid – Also known as blood plasma, this is the fluid that surrounds blood cells in the blood vessels.


1. To be used by mitochondria, oxygen must make its way from the lungs to inside the cells in the tissues of an animal. Which of the following fluids does the oxygen molecule NOT pass through?
A. Transcellular Fluid
B. Extracellular Fluid
C. Intracellular Fluid

Answer to Question #1
A is correct. On its way to each cell, the oxygen will pass through all the types of extracellular fluid except the transcellular fluid. Plus, the oxygen must pass through the intracellular fluid in the cells of the lungs, through cells of the blood vessels and finally into the cytosol of the final cell.