Home Biochemistry Recessive Allele


Gardnerella vaginalis

Gardnerella Vaginalis

Definition Gardnerella vaginalis is the name of a micro-aerophilic coccobacillus found in the vaginal flora. Gardnerella vaginalis does not cause bacterial vaginosis (vaginal infection) unless...
Acetic Acid

Acetic Acid

Definition Acetic acid is a mildly corrosive monocarboxylic acid. Otherwise known as ethanoic acid, methanecarboxylic acid, hydrogen acetate or ethylic acid, this organic compound is...
Amino Acids

Amino Acids

Definition Amino acids are the building blocks of polypeptides and proteins and play important roles in metabolic pathway, gene expression, and cell signal transduction regulation....
BCAA supplements: a muscle myth?

Branched Chain Amino Acids

Definition The branched-chain amino acids or BCAAs, leucine, isoleucine, and valine are three of the nine nutritionally essential amino acids. These three ingredients form a...
Sulfuric acid

Sulfuric Acid

Definition Sulfuric acid (sulphuric acid) is a corrosive mineral acid with an oily, glassy appearance that gave it its earlier name of oil of vitriol....
Bile salt action in the gut

Bile Salts

Definition Bile salts are found in bile, a secretion produced by liver cells to aid digestion. Although bile is 95% water, bile salts are its...
The salivary glands

Submandibular Gland

Definition Submandibular glands are the second-largest salivary gland type, producing around 65% of our saliva when unstimulated (at rest). Located under the jaw, the exocrine...
Metaphase I

Metaphase I

Definition The first metaphase of meisosis I encompasses the alignment of paired chromosomes along the center (metaphase plate) of a cell, ensuring that two complete...
Prophase II

Prophase II

Definition During prophase II of meiosis II, four important steps occur. These are the condensing of chromatin into chromosomes, disintegration of the nuclear envelope, migration...


Definition Aldosterone (C21H28O5) is a mineralocorticoid hormone compound secreted by the adrenal gland cortex. It is part of the renin angiotensin aldosterone system or RAAS...

Recessive Allele

Recessive Allele Definition

A recessive allele is a variety of genetic code that does not create a phenotype if a dominant allele is present. In a dominant/recessive relationship between two alleles, the recessive allele’s effects are masked by the more dramatic effects of the dominant allele. An allele is a specific variation of a gene, or specific segment of DNA. Different alleles produce slightly different proteins, which function in different ways.

In dominant/recessive relationships, the recessive allele produces a non-functional protein. The dominant allele produces a functioning protein. A heterozygous individual will appear the same as a homozygous dominant individual. This means that an organisms with two dominant alleles appear the same as an organism with only one functioning allele. Many enzymes are able to process their substrates so fast that one functional allele can produce enough enzyme to service the needs of the organism. Most enzymes are regulated anyway through a variety of methods, and are not allowed to convert substrate to their full potential.

A common misconception is that a recessive allele is somehow worse, evolutionarily, than a dominant allele. Natural selection may select for a recessive allele if the products of a dominant allele are unfavorable in the environment that a population is living in. While genes only code for proteins, these proteins interact in ways that build and create the entire structure of an organism. Sometimes, not having an enzyme functioning is more beneficial than having it.

Examples of Recessive Allele

Coat Color

In many animals with hair, coat color is in part determined by a gene that controls melanin production. Melanin is an important pigment that colors the hair black or brown, depending on its concentration. The gene partially responsible for melanin production produces the enzyme that converts melanin from an intermediate molecule to a functional pigment molecule. The recessive allele for melanin production produces an enzyme that does not function in converting the intermediate molecule.

Suppose a population of black rabbits is set adrift in a small boat. The boat crashes on a cold island, covered almost year-round in snow. There are only a few predators on the island, so they can’t eat all the rabbits at once. Now suppose that two black rabbits, both heterozygous for the melanin gene, start to reproduce. According to a Punnett square, a homozygous recessive individual will be created between the parents at least 25% of the time. These individuals will not be able to produce melanin, and will be white. In this generation, the black rabbits get eaten much more than the white rabbits. As such, the white rabbits get more opportunities to reproduce.

If they produce successful offspring, the white recessive allele will increase in frequency in the population. Eventually, the predator will eat all or most of the black rabbits. Although the black allele will decrease in frequency, it will still be the dominant allele. This means it will still only take one black allele to produce a black phenotype, although the total number of black alleles in the population will be severely decreased.

Tay-Sachs Disease

Tay-Sachs disease is a recessive disorder, causes by non-functioning alleles in the HEXA gene. The gene codes for several lysosomal enzymes. The enzymes it codes for, beta-N-acetylhexosaminidase A and others, are responsible for the breakdown of certain lipids. If these lipids cannot be broken down, they rapidly accumulate in the brain and interfere with many processes. The mutations that cause Tay-Sachs can arise in several areas of the gene, and create enzymes with different functionalities.

People with Tay-Sachs disease experience different onset timeframes for their symptoms, as a result of the complex action of the recessive alleles. Recessive alleles caused by different mutations produce enzymes that vary in their level of functioning. Although two recessive alleles means you will get the disease, when the disease will strike is still a mystery. Heterozygous individuals show no disease symptoms, because one functioning enzyme is enough to rid the cells of excess lipids. Because it only takes one dominant allele to produce a functioning phenotype, Tay-Sachs is considered a recessive disorder.

  • Dominant – An allele with the ability to hide the effects of a non-dominant allele.
  • Heterozygous – An individual with two alleles of different type.
  • Allele Frequency – The number of a certain type of allele, divided by the total number of alleles in a population.
  • Natural Selection – The process by which allele frequencies in populations are changed in response to the environment.


1. A new mutation in a gene causes a new molecule to be produced. The enzyme the new allele encodes for is very slow at making the molecule, but the molecule is very beneficial to the organism. To produce enough of the molecule to be beneficial, two mutated alleles are needed. If only one mutated allele is present, the organism appears “normal”. What relationship does the mutated allele have with the normal allele?
A. Mutated allele is dominant.
B. Mutated allele is recessive.
C. Mutated allele is codominant.

Answer to Question #1
B is correct. The mutated allele is recessive to the wild type allele, because a wild type allele will produce a normal phenotype. Although the recessive allele still produces a functional enzyme, it is not functional enough to produce phenotypic change without two copies present. That makes it recessive to the normal, wild-type allele.

2. Two people want to have a baby. They come from families that have both had cases of the same autosomal recessive traits. Why is it a good idea for them to get genetically tested?
A. They could be carriers of the genetic diseases.
B. They can guarantee their baby will not get a disease.
C. If you don’t pass your genetics test, you won’t graduate.

Answer to Question #2
A is correct. Although C is probably also true, A is the correct answer. By getting genetically tested, parents can understand their chances of passing on genetic diseases to their children. Genetic tests in no way guarantee the absence of disease, but can help parents avoid certain genetic diseases.

3. Bacteria have a single ring of DNA. Therefore, a single bacteria can only express one allele. Can bacterial alleles be dominant and recessive?
A. No
B. Yes
C. Only if they sexually reproduce

Answer to Question #3
A is correct. If only one allele is expressed at a time, the different alleles can have no relationship. They will still be selected against by the forces of nature, and more successful alleles will increase in frequency. The traits of dominant and recessive only apply in organisms with two versions of an allele that can form a relationship in the phenotype they produce.